{"id":3005,"date":"2025-10-25T00:05:43","date_gmt":"2025-10-24T16:05:43","guid":{"rendered":"https:\/\/www.nobelstars.cn\/?p=3005"},"modified":"2025-10-25T00:05:47","modified_gmt":"2025-10-24T16:05:47","slug":"%e8%af%ba%e5%a5%96%e7%ba%a7%e5%90%88%e4%bd%9c%e6%9c%ba%e9%81%87%ef%bc%9a%e5%85%8d%e7%96%ab%e5%ad%a6%e4%b9%8b%e7%88%b6-rolf-m-zinkernagel-9-%e6%9c%88%e4%b8%ad%e5%9b%bd%e4%b9%8b","status":"publish","type":"post","link":"https:\/\/www.nobelstars.cn\/?p=3005","title":{"rendered":"\u8bfa\u5956\u7ea7\u5408\u4f5c\u673a\u9047\uff1a\u201c\u514d\u75ab\u5b66\u4e4b\u7236\u201d Rolf M. Zinkernagel 9 \u6708\u4e2d\u56fd\u4e4b\u65c5\u5f00\u542f\u5728\u5373"},"content":{"rendered":"<section>\n<section>\n<section>\n<section><strong>\u4eca\u5e74 9 \u6708\uff0c\u79d1\u5b66\u754c\u5c06\u8fce\u6765\u4e00\u573a\u4ee4\u4eba\u77a9\u76ee\u7684\u76db\u4e8b \u2014\u2014 \u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5f97\u4e3b Rolf M. Zinkernagel \u5373\u5c06\u8bbf\u534e\u3002<\/strong>\u8fd9\u4e00\u6d88\u606f\u5728\u79d1\u7814\u5708\u8fc5\u901f\u4f20\u5f00\uff0c\u5f15\u53d1\u5e7f\u6cdb\u5173\u6ce8\uff0c\u5927\u5bb6\u7eb7\u7eb7\u671f\u5f85\u7740\u6b64\u6b21\u8bbf\u95ee\u80fd\u4e3a\u56fd\u5185\u79d1\u7814\u9886\u57df\u5e26\u6765\u65b0\u7684\u6d3b\u529b\u4e0e\u5408\u4f5c\u673a\u9047\u3002<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3011 aligncenter\" src=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/6-8-640x853.jpg\" alt=\"\" width=\"640\" height=\"853\" srcset=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/6-8-640x853.jpg 640w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/6-8-768x1024.jpg 768w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/6-8-320x427.jpg 320w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/6-8.jpg 1000w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><strong>\u4e00\u3001\u201c\u514d\u75ab\u5b66\u4e4b\u7236\u201d\u7684\u4f20\u5947\u6210\u957f\u53f2<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>Rolf M. Zinkernagel \u7684\u5b66\u672f\u6210\u957f\u4e4b\u8def\u582a\u79f0\u4f20\u5947\u3002\u4ed6\u51fa\u751f\u4e8e\u745e\u58eb\uff0c\u65e9\u5e74\u5728\u82cf\u9ece\u4e16\u5927\u5b66\u5f00\u542f\u5b66\u672f\u63a2\u7d22\uff0c\u6700\u521d\u5b66\u4e60\u7684\u662f\u533b\u5b66\u3002<strong>\u5728\u6c42\u5b66\u671f\u95f4\uff0c\u4ed6\u4fbf\u5c55\u73b0\u51fa\u5bf9\u514d\u75ab\u5b66\u72ec\u7279\u7684\u6d1e\u5bdf\u529b\u548c\u6d53\u539a\u5174\u8da3\uff0c\u8fd9\u4e3a\u4ed6\u65e5\u540e\u5728\u8be5\u9886\u57df\u53d6\u5f97\u5353\u8d8a\u6210\u5c31\u57cb\u4e0b\u4e86\u79cd\u5b50\u3002<\/strong><strong>1996 \u5e74\uff0c\u662f Rolf M. Zinkernagel \u5b66\u672f\u751f\u6daf\u7684\u9ad8\u5149\u65f6\u523b\u3002\u4ed6\u4e0e\u5f7c\u5f97\u30fb\u675c\u8d6b\u63d0\uff08Peter Doherty\uff09\u56e0\u5728\u514d\u75ab\u7cfb\u7edf\u7814\u7a76\u4e2d\u7684\u91cd\u5927\u53d1\u73b0\uff0c\u5171\u540c\u8363\u83b7\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/strong>\u4ed6\u4eec\u63ed\u793a\u4e86\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684 \u201c\u6740\u624b\u201d T \u7ec6\u80de\uff0c\u662f\u901a\u8fc7\u4e00\u79cd\u540d\u4e3a \u201c\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\u201d\uff08MHC\uff09\u7684\u5206\u5b50\uff0c\u6765\u7cbe\u51c6\u8bc6\u522b\u5e76\u653b\u51fb\u5916\u6765\u75c5\u6bd2\u6216\u88ab\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u673a\u5236\u3002\u8fd9\u4e00\u7a81\u7834\u6027\u53d1\u73b0\uff0c\u72b9\u5982\u4e00\u9053\u5149\uff0c\u7167\u4eae\u4e86\u514d\u75ab\u5b66\u7814\u7a76\u7684\u524d\u884c\u9053\u8def\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u4eba\u4eec\u5bf9\u514d\u75ab\u7cfb\u7edf\u5de5\u4f5c\u539f\u7406\u7684\u8ba4\u77e5\uff0c\u5bf9\u540e\u7eed\u75ab\u82d7\u7814\u53d1\u3001\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7b49\u591a\u4e2a\u533b\u5b66\u9886\u57df\u4ea7\u751f\u4e86\u6df1\u8fdc\u5f71\u54cd\uff0c\u4e3a\u65e0\u6570\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u5e0c\u671b\u3002<strong>\u5728\u6b64\u540e\u7684\u5c81\u6708\u91cc\uff0c\u4ed6\u59cb\u7ec8\u6d3b\u8dc3\u5728\u79d1\u7814\u4e00\u7ebf\uff0c\u4efb\u804c\u4e8e\u82cf\u9ece\u4e16\u5927\u5b66\uff0c\u62c5\u4efb\u5b9e\u9a8c\u514d\u75ab\u5b66\u6559\u6388\u53ca\u5b9e\u9a8c\u514d\u75ab\u5b66\u7814\u7a76\u6240\u6240\u957f\uff0c\u6301\u7eed\u6df1\u8015\u514d\u75ab\u5b66\u9886\u57df\uff0c\u4e0d\u65ad\u62d3\u5c55\u4eba\u7c7b\u5bf9\u514d\u75ab\u7cfb\u7edf\u8ba4\u77e5\u7684\u8fb9\u754c\u3002<\/strong><\/p>\n<\/section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3007 aligncenter\" src=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/2-11-640x435.jpg\" alt=\"\" width=\"640\" height=\"435\" srcset=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/2-11-640x435.jpg 640w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/2-11-768x522.jpg 768w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/2-11-320x217.jpg 320w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/2-11.jpg 1080w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section><\/section>\n<section>\n<section>\n<section>\n<section>\n<section><strong>\u4e8c\u3001\u514d\u75ab\u5b66\u754c\u4e00\u4ee3\u5b97\u5e08\uff0c\u5b9e\u529b\u8d85\u4e4e\u60f3\u8c61<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><strong>\u514d\u75ab\u5b66\u754c\u5b97\u5e08\uff1a\u5b9a\u4e49\u751f\u547d\u9632\u5fa1\u79d1\u5b66\u7684\u8bfa\u5956\u5de8\u64d8<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\u4f5c\u4e3a \u201c\u514d\u75ab\u5b66\u4e4b\u7236\u201d\u3001\u745e\u58eb\u82cf\u9ece\u4e16\u5927\u5b66\u5b9e\u9a8c\u514d\u75ab\u5b66\u7814\u7a76\u6240\u540d\u8a89\u6559\u6388\u3001\u591a\u56fd\u79d1\u5b66\u9662\u9662\u58eb\uff08\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662 \/ \u5fb7\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662 \/ \u82f1\u56fd\u7687\u5bb6\u5b66\u4f1a\u7b49\uff09\uff0c<strong>Rolf M. Zinkernagel \u4ee5 \u201c\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u5206\u5b50\u673a\u5236\u201d \u8fd9\u4e00\u7a81\u7834\u6027\u53d1\u73b0\u6458\u5f97 1996 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff0c\u4e3a\u5168\u7403\u514d\u75ab\u5b66\u7814\u7a76\u5960\u5b9a\u91cc\u7a0b\u7891\u5f0f\u57fa\u7840\uff0c\u5176\u6210\u679c\u81f3\u4eca\u4ecd\u662f\u514d\u75ab\u5b66\u79d1\u7684\u6838\u5fc3\u7406\u8bba\u652f\u67f1\u3002<\/strong><\/section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3008 aligncenter\" src=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/3-8-640x853.jpg\" alt=\"\" width=\"640\" height=\"853\" srcset=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/3-8-640x853.jpg 640w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/3-8-768x1024.jpg 768w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/3-8-320x427.jpg 320w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/3-8.jpg 1000w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/section>\n<\/section>\n<section><\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><strong>\u00a0\u9876\u5c16\u8d44\u8d28\u77e9\u9635\uff1a\u4ece\u79d1\u7814\u5dc5\u5cf0\u5230\u884c\u4e1a\u7edd\u5bf9\u8bdd\u8bed\u6743<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section><strong>\u5168\u7403\u5b66\u672f\u9886\u822a\u8005\uff1a<\/strong>\u66fe\u4efb\u56fd\u9645\u514d\u75ab\u5b66\u4f1a\u8054\u5408\u4f1a\u4e3b\u5e2d\u3001\u745e\u58eb\u53d8\u6001\u53cd\u5e94\u4e0e\u514d\u75ab\u5b66\u5b66\u4f1a\u4e3b\u5e2d\uff0c\u4e3b\u5bfc\u5168\u7403\u514d\u75ab\u5b66\u7814\u7a76\u65b9\u5411\uff0c\u5b66\u672f\u5f71\u54cd\u529b\u6a2a\u8de8\u4e94\u5927\u6d32\uff1b<strong>\u8363\u8a89\u4f53\u7cfb\u5168\u6ee1\u8d2f\uff1a<\/strong>\u65a9\u83b7 Albert Lasker \u57fa\u7840\u533b\u5b66\u7814\u7a76\u5956\uff08\u8bfa\u5956\u98ce\u5411\u6807\uff09\u3001\u5339\u5179\u5821 Starzl \u5956\u7b49\u6570\u5341\u9879\u56fd\u9645\u9876\u7ea7\u8363\u8a89\uff0c\u79d1\u7814\u786c\u5b9e\u529b\u83b7\u5168\u7403\u5b66\u672f\u754c\u516c\u8ba4\uff1b<\/p>\n<p><strong>\u9876\u5c16\u5e73\u53f0\u80cc\u4e66\uff1a<\/strong>\u624e\u6839 \u201c\u8bfa\u5956\u6447\u7bee\u201d \u82cf\u9ece\u4e16\u5927\u5b66\uff0812 \u4f4d\u8bfa\u5956\u5f97\u4e3b\u6bcd\u6821\uff09\u6570\u5341\u5e74\uff0c\u4ece\u5b9e\u9a8c\u514d\u75ab\u5b66\u7814\u7a76\u6240\u6240\u957f\u5230\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u6559\u6388\uff0c\u8db3\u8ff9\u904d\u5e03\u5168\u7403\u9876\u5c16\u79d1\u7814\u673a\u6784\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3009 aligncenter\" src=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/4-9-640x472.jpg\" alt=\"\" width=\"640\" height=\"472\" srcset=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/4-9-640x472.jpg 640w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/4-9-320x236.jpg 320w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/4-9.jpg 760w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<section>\n<section><strong>\u4e09\u30019 \u6708\u4e2d\u56fd\u4e4b\u65c5\uff0c<\/strong><strong>\u54c1\u724c\u9ad8\u7aef\u5316\u7684\u9ec4\u91d1\u80cc\u4e66\u673a\u9047<\/strong><\/section>\n<\/section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\u8fd9\u4f4d\u6df1\u8015\u514d\u75ab\u5b66\u9886\u57df\u534a\u4e16\u7eaa\u7684 \u201c\u5b66\u754c\u5b97\u5e08\u201d\uff0c\u5c06\u5e26\u7740\u5bf9\u514d\u75ab\u673a\u5236\u7684\u524d\u6cbf\u6d1e\u5bdf\u4e0e\u5168\u7403\u8d44\u6e90\u6765\u534e\u3002<strong>\u65e0\u8bba\u662f\u54c1\u724c\u5b66\u672f\u80cc\u4e66\u3001\u4ea7\u54c1\u79d1\u7814\u8f6c\u5316\u3001\u9ad8\u7aef\u8bba\u575b\u5408\u4f5c\uff0c\u8fd8\u662f\u514d\u75ab\u5065\u5eb7\u8d5b\u9053\u7684\u4ef7\u503c\u5347\u7ea7\uff0c\u5176 \u201c\u514d\u75ab\u5b66\u4e4b\u7236 + \u8bfa\u5956\u5f97\u4e3b\u201d \u7684\u53cc\u91cd\u6743\u5a01\u8eab\u4efd\uff0c\u90fd\u5c06\u4e3a\u54c1\u724c\u6ce8\u5165\u4e0d\u53ef\u590d\u5236\u7684\u4e13\u4e1a\u516c\u4fe1\u529b\uff0c\u52a9\u529b\u54c1\u724c\u5728\u5065\u5eb7\u79d1\u6280\u9886\u57df\u6811\u7acb \u201c\u79d1\u7814\u9a71\u52a8\u201d \u7684\u9ad8\u7aef\u5f62\u8c61\uff0c\u62a2\u5360\u5e02\u573a\u8bdd\u8bed\u6743\u3002<\/strong><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3010 aligncenter\" src=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/5-12-640x460.png\" alt=\"\" width=\"640\" height=\"460\" srcset=\"https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/5-12-640x460.png 640w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/5-12-768x552.png 768w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/5-12-320x230.png 320w, https:\/\/www.nobelstars.cn\/wp-content\/uploads\/2025\/10\/5-12.png 1026w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section><strong>\u6838\u5fc3\u5408\u4f5c\u4ef7\u503c\uff1a<\/strong>1\u3001\u8bfa\u5956\u7ea7 IP \u80cc\u4e66\uff0c\u77ac\u95f4\u63d0\u5347\u54c1\u724c\u4e13\u4e1a\u9ad8\u5ea6\u4e0e\u56fd\u9645\u8fa8\u8bc6\u5ea6\uff1b<\/p>\n<p>2\u3001\u6df1\u5ea6\u94fe\u63a5\u514d\u75ab\u79d1\u5b66\u524d\u6cbf\u8d44\u6e90\uff0c\u4e3a\u4ea7\u54c1\u7814\u53d1\u63d0\u4f9b\u6743\u5a01\u7406\u8bba\u652f\u6491\uff1b<\/p>\n<p>3\u3001\u501f\u52bf \u201c\u514d\u75ab\u5b66\u4e4b\u7236\u201d \u5f71\u54cd\u529b\uff0c\u5f3a\u5316\u54c1\u724c\u5728\u5065\u5eb7\u9886\u57df\u7684\u6743\u5a01\u6027\u4e0e\u4fe1\u4efb\u611f\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u5e74 9 \u6708\uff0c\u79d1\u5b66\u754c\u5c06\u8fce\u6765\u4e00\u573a\u4ee4\u4eba\u77a9\u76ee\u7684\u76db\u4e8b \u2014\u2014 \u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5f97\u4e3b Rolf M. Zinkerna&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3005","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=\/wp\/v2\/posts\/3005","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3005"}],"version-history":[{"count":2,"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=\/wp\/v2\/posts\/3005\/revisions"}],"predecessor-version":[{"id":3013,"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=\/wp\/v2\/posts\/3005\/revisions\/3013"}],"wp:attachment":[{"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3005"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3005"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nobelstars.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}